| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A portion of amino acids 123-150 from the human protein was used as the immunogen for this BASP1 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
BASP1 Antibody / Brain acid soluble protein 1 is an antibody targeting BASP1, raised in Rabbit for protein detection and localization studies where these specifications are required.
Key elements and design rationale
- Target: BASP1.
- Antibody identity: Polyclonal (rabbit origin); Rabbit Ig.
- Conjugate/label: Unconjugated (affects detection chemistry and multiplex compatibility).
- Format: Antigen affinity purified.
- Species reactivity: Human.
- Listed applications: WB (refer to on-page specifications for application-specific guidance).
Biological background
BASP1, or Brain acid soluble protein 1, and also known as NAP22 or CAP-23, is a highly conserved protein found in the brain and nervous system. It plays a pivotal role in regulating neuronal growth, synaptic plasticity, and cell signaling. BASP1 is known to interact with various cellular proteins and lipids, influencing processes such as axonal growth, neurotransmitter release, and neuroprotection. Research has shown that BASP1 is involved in a multitude of cellular processes that are essential for proper brain function. It plays a crucial role in promoting dendritic branching, axonal outgrowth, and neuronal migration during brain development. Additionally, BASP1 is implicated in regulating the release of neurotransmitters such as dopamine and acetylcholine, which are crucial for cognitive functions. Given its pivotal role in brain function, BASP1 dysregulation has been linked to various neurological disorders. Studies have shown that abnormal levels of BASP1 expression are associated with conditions such as Alzheimer's disease, Parkinson's disease, and schizophrenia.
Research relevance and current trends
- Comparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).
- Subcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.
- Integration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.
Common research applications
- Western blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative/positive controls for interpretation.
Interpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.
Notes for experimental interpretation
- Isoforms and PTMs: many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands/signals accordingly.
- Epitope context: binding can depend on protein conformation and sample processing; region information in the title/immunogen can help anticipate what may be detected.
- Species differences: predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.
- Control concepts: include negative controls (no-primary/isotype), and where possible genetic controls (KO/KD) or independent antibodies to strengthen conclusions.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
