C16

C16 is a derivative of imidazolo-oxindole and functions as a selective inhibitor of RNA-dependent protein kinase (PKR), a key regulator of cellular stress responses. By targeting the ATP-binding site of PKR, C16 effectively blocks the PKR/eIF2α signaling pathway, which is implicated in apoptosis and neuroinflammation. In neurodegenerative disease research, C16 has gained attention for its potential to mitigate neuronal cell death and reduce inflammatory cascades associated with conditions such as Alzheimer’s and Parkinson’s disease. Its ability to modulate stress-induced translational control makes it a valuable tool for studying neuroprotective mechanisms and therapeutic interventions in central nervous system disorders.

Classification: Chronic aquatic toxicity (Category 4), H413

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

H413 May cause long lasting harmful effects to aquatic life.

Precautionary statements:

• P273 Avoid release to the environment.
• P501 Dispose of contents/ container to an approved waste disposal plant.

C16 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-498)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).