| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide, PR-17, Carfilzomib, Kyprolis, Carfilzomib (PR-171), PR-171, UNII-72X6E3J5AR |
| Cas No. | |
| Form | White powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (80 mg/ml), or ethanol (25 mg/ml) |
| Source | Synthetic |
| Storage |
Carfilzomib is an irreversible proteasome inhibitor that selectively targets the chymotrypsin-like activity of the 20S proteasome. While primarily developed as an anticancer agent, Carfilzomib has relevance in neurodegenerative disease research due to its impact on protein homeostasis. By modulating the ubiquitin-proteasome system, Carfilzomib helps elucidate mechanisms of protein aggregation and clearance, which are central to diseases like Alzheimer’s, Parkinson’s, and ALS. Its role in inducing apoptosis and cell cycle arrest also provides insights into neuronal vulnerability and stress responses.
Classification: Not WHMIS controlled.
Hazard statements:
- H302 Harmful if swallowed.
- H315 Causes skin irritation.
- H319 Causes serious eye irritation.
- H335 May cause respiratory irritation.
Precautionary statements:
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
- P280 Wear protective gloves/protective clothing/eye protection/face protection.
- P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
- P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Carfilzomib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-544)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
