| Field | Specification |
|---|---|
| Mfr No | |
| Accession Number | |
| Alternative Names | Voltage-dependent L-type calcium channel subunit alpha-1C, Cav1.2, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, Voltage-gated calcium channel subunit alpha Cav1.2, DHPR alpha-1 subunit, CACH3, CACN4, CACNL1A2, alpha-1 subunit voltage-dependent calcium channel, calcium channel voltage-dependent L type alpha 1C subunit1, calcium channel L type, alpha 1 polypeptide isoform 1 cardiac muscle, calcium channel cardiac dihydropyridine-sensitive alpha-1 subunit, voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit splice variant 10 |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | Fusion protein amino acids 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2 |
| Isotype | |
| Product Type | |
| Reactivity | |
| Shipping | |
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| Target |
Cav1.2, encoded by the CACNA1C gene, is a major subunit of the L-type voltage-gated calcium channel family, best known for its role in cardiac excitation-contraction coupling. However, beyond the heart, Cav1.2 is highly expressed in the brain, where it regulates calcium influx critical for neuronal excitability, synaptic plasticity, and gene transcription.
Dysregulation of Cav1.2 has been implicated in a range of neurological and neuropsychiatric disorders. Mutations in CACNA1C are causally linked to Timothy syndrome, a rare multisystem disorder characterized by cardiac arrhythmias, autism spectrum features, and cognitive impairment. Additionally, variants in CACNA1C have been associated with Brugada syndrome and are increasingly recognized as genetic risk factors for bipolar disorder, schizophrenia, and major depressive disorder.
In the context of neurodegenerative disease, altered Cav1.2 function may contribute to disrupted calcium homeostasis, oxidative stress, and neuronal vulnerability—hallmarks of conditions such as Alzheimer’s and Parkinson’s disease. Its role in activity-dependent gene expression also positions Cav1.2 as a key modulator of long-term neuronal survival and plasticity.
Given its dual importance in cardiac and neural physiology, Cav1.2 is a promising target for therapeutic strategies aimed at restoring calcium signaling balance in both neurodevelopmental and neurodegenerative disorders.
1 µg/ml of SMC-300 was sufficient for detection of Cav1.2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-300D — Size: 100 ug: Cav1.2 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-300D, RRID: AB_2069099)
- SMC-300D-A390 — Size: 100 ug: Cav1.2 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-300D-A390, RRID: AB_2700006)
- SMC-300D-A488 — Size: 100 ug: Cav1.2 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-300D-A488, RRID: AB_2700007)
- SMC-300D-A594 — Size: 100 ug: Cav1.2 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-300D-A594, RRID: AB_2700009)
- SMC-300D-APC — Size: 100 ug: Cav1.2 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-300D-APC, RRID: AB_2700015)
- SMC-300D-BI — Size: 100 ug: Cav1.2 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-300D-BI, RRID: AB_2700016)
- SMC-300D-FITC — Size: 100 ug: Cav1.2 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-300D-FITC, RRID: AB_2700017)
- SMC-300D-HRP — Size: 100 ug: Cav1.2 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-300D-HRP, RRID: AB_2700018)
- SMC-300D-PCP — Size: 100 ug: Cav1.2 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-300D-PCP, RRID: AB_2700020)
- SMC-300D-RPE — Size: 100 ug: Cav1.2 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-300D-RPE, RRID: AB_2700021)
- SMC-300S — Size: 12 ug: Cav1.2 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-300S, RRID: AB_2069099)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Krey J.F., and Dolmetsch R. (2009) Biophysical. 96 (3): 221a-222a.
3. Crotti L., Celano G., Dagradi F. and Schwartz P.J. (2008) Orphanet J Rare Disease 3:18.
