| Field | Specification |
|---|---|
| Mfr No | |
| Accession Number | |
| Alternative Names | Voltage-dependent T-type calcium channel subunit alpha-1H, Voltage-gated calcium channel subunit alpha Cav3.2, CACNA1H, KIAA1120, Cav3.2, CACNA1HB, calcium channel, voltage-dependent, T type, alpha 1H subunit, alpha 1Hb subunit, ECA6, EIG6, FLJ90484, Low-voltage-activated calcium channel alpha1 3.2 subunit, low-voltage-activated calcium channel alpha13.2 subunit, voltage dependent t-type calcium channel alpha-1H subunit, voltage-dependent T-type calcium channel subunit alpha-1H, voltage-gated calcium channel alpha subunit Cav3.2, voltage-gated calcium channel alpha subunit CavT.2 |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | Fusion protein amino acids 1019-1293 (II-III loop) of human Cav3.2 |
| Isotype | |
| Product Type | |
| Reactivity | |
| Shipping | |
| Storage | |
| Target |
Cav3.2, encoded by the CACNA1H gene, is a low-voltage-activated T-type calcium channel that plays a critical role in regulating neuronal excitability, rhythmic firing, and calcium homeostasis. It is widely expressed in the brain and peripheral tissues, where it contributes to burst firing in thalamic neurons and modulates sensory signal transmission.
Genetic studies have linked mutations in CACNA1H to childhood absence epilepsy, highlighting Cav3.2’s role in thalamocortical oscillations and seizure susceptibility. Beyond epilepsy, dysregulation of Cav3.2 expression and function has been associated with broader neurological and neurodegenerative conditions, including neuropathic pain, Parkinson’s disease, and Alzheimer’s disease. Its involvement in calcium dysregulation—a hallmark of neurodegeneration—positions Cav3.2 as a potential therapeutic target for modulating neuronal survival and excitability.
Interestingly, Cav3.2 is also implicated in non-neuronal pathologies, such as prostate cancer progression, where its upregulation may support androgen-independent tumor growth. This underscores the channel’s broader physiological relevance and potential as a drug target across multiple disease domains.
Despite its clinical significance, many aspects of Cav3.2’s in vivo function, regulatory mechanisms, and disease-specific roles remain under investigation. Advancing our understanding of Cav3.2 could open new avenues for targeted therapies in epilepsy, neurodegeneration, and beyond.
1 µg/ml of SMC-303 was sufficient for detection of Cav3.2 in 10 µg of HEK cell lysate expressing Cav3.2 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-303D — Size: 100 ug: Cav3.2 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-303D, RRID: AB_2069540)
- SMC-303D-A390 — Size: 100 ug: Cav3.2 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-303D-A390, RRID: AB_2700057)
- SMC-303D-A488 — Size: 100 ug: Cav3.2 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-303D-A488, RRID: AB_2700058)
- SMC-303D-A594 — Size: 100 ug: Cav3.2 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-303D-A594, RRID: AB_2700060)
- SMC-303D-APC — Size: 100 ug: Cav3.2 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-303D-APC, RRID: AB_2700066)
- SMC-303D-BI — Size: 100 ug: Cav3.2 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-303D-BI, RRID: AB_2700067)
- SMC-303D-FITC — Size: 100 ug: Cav3.2 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-303D-FITC, RRID: AB_2700068)
- SMC-303D-HRP — Size: 100 ug: Cav3.2 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-303D-HRP, RRID: AB_2700069)
- SMC-303D-PCP — Size: 100 ug: Cav3.2 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-303D-PCP, RRID: AB_2700071)
- SMC-303D-RPE — Size: 100 ug: Cav3.2 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-303D-RPE, RRID: AB_2700072)
- SMC-303S — Size: 12 ug: Cav3.2 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-303S, RRID: AB_2069540)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Khosravani H., et al. (2004) J Biol Chem. 279(11): 9681-9684.
3. Gackiere F., et al. (2008) J Biol Chem. 283(28): 19872.
