| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: N-[(2S)-1-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]naphthalene-2-carboxamide.
- Also known as: (S)-N-(1-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide.
- CAS number: 1130067-06-9
- Molecular formula: C26H27ClN4O2.
- Purity: >95%
- Concentration: 1-10 µM.
- Form: Lyophilized Powder
- Solubility: Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
- Reconstitution: Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: P2X7 receptors, Phospholipase D1 (PLD1)
- Source: Synthetic
- Activity: CAY10593 (VU0155069) is an antagonist of purinergic P2X7 receptors, shown to inhibit ATP-induced ethidium+ uptake in RPMI 8226 cells with IC50 of 2 µM1. It is also a potent and selective inhibitor of phospholipase D1 (IC50 of 46 and 933 nM for PLD1 and PLD2, respectively)2.
- Alternative names: (S)-N-(1-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide.
Scientific background
CAY10593 (VU0155069) is an antagonist of purinergic P2X7 receptors and an inhibitor of phospholipase D1 (PLD1)1. CAY10593 inhibits ATP-induced ethidium+ uptake in RPMI 8226 cells expressing P2X7 receptors in a concentration-dependent manner with an IC50 value of 2 µM1.The P2X receptors are a family of ligand-gated ion channels present on various cell types. P2X receptors are activated by extracellular ATP and play an important role in many disease states, including inflammatory, immune, neoplastic, musculoskeletal, and neurological disorders1,2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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