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Compound Overview
CCR4 antagonist 2 (CAS 2206788-99-8) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 2206788-99-8 |
|---|---|
| Molecular Formula | C26H28Cl2N6O |
| Molecular Weight | 511.45 g/mol |
| SMILES | (CH)(C)(N1C=2C(C(CN)=N1)=NC=C(N2)C=3C(CH)(C)(CH)(CC3)N4(CH)(CO)CCC4)C5… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.
Target(s): Calcium Channel
Signaling pathway(s): Membrane transporter/Ion channel, Metabolism
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Most small molecule inhibitors are not compatible with autoclaving (121 °C), which can cause thermal decomposition or loss of biological activity. For sterile cell-based experiments, filter-sterilize working solutions through a 0.2 µm membrane after dilution into aqueous buffer. Verify thermal stability in the DataSheet before applying any heat treatment.
When solubility is listed as < 1 mg/mL, the compound dissolves to less than 1 mg per milliliter in water at 25 °C, pH 7.4. Such compounds require an organic co-solvent such as DMSO to prepare a concentrated stock, which is then diluted into aqueous assay buffer. For cell-based assays, keep the final DMSO concentration below 0.1% (v/v) to avoid solvent-induced cytotoxicity.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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