| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea, CCT-196969, CCT 196969 |
| Cas No. | |
| Form | White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO |
| Source | Synthetic |
| Storage |
CCT196969 is a dual pan-RAF/SFK inhibitor with potent activity against BRAF and SRC kinases. While primarily developed for melanoma treatment, its inhibition of SRC kinase—a key player in neuronal signaling—suggests potential applications in neuroscience. SRC kinases are involved in synaptic plasticity and neuroinflammation, and their dysregulation is linked to neurodegenerative diseases. CCT196969’s ability to modulate these pathways may offer therapeutic insights into CNS disorders characterized by aberrant kinase activity.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
CCT196969 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-185)
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
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