| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human CD163L1 was used as the immunogen for the CD163L1 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
CD163L1 Antibody / CD163 like 1 / CD163b is a anti-CD163L1 Rabbit antibody Recombinant Rabbit Monoclonal clone 31C59 supplied in Liquid format. Recommended for workflows such as Immunohistochemistry (IHC) with listed reactivity in Human. Reported localization: Cytoplasm.
Key elements and design rationale
- Target: CD163L1
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 31C59, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): IHC
Biological background
CD163 like 1 is a member of the scavenger receptor cysteine-rich family and localizes to the plasma membrane of immune cells. Research using CD163L1 antibody has shown that this receptor binds hemoglobin haptoglobin complexes and other ligands, contributing to clearance of hemoglobin and modulation of inflammation. Unlike CD163, CD163L1 expression is restricted to specific immune cell subsets, suggesting specialized functions in innate defense.
In immune regulation, CD163L1 influences cytokine responses and macrophage polarization. Studies with CD163L1 antibody have demonstrated that its engagement alters production of pro- and anti-inflammatory mediators, shaping immune responses during infection and tissue repair. Dysregulation of CD163L1 expression has been associated with chronic inflammation and autoimmune disorders.
Beyond immunity, CD163L1 has been implicated in cardiovascular and metabolic diseases. Research using CD163L1 antibody has revealed associations with atherosclerosis, where scavenger receptor activity influences lipid uptake and foam cell formation. In metabolic disease, altered expression may contribute to chronic low-grade inflammation in obesity and diabetes. These findings expand the role of CD163L1 beyond classical scavenger functions to systemic disease processes.
CD163L1 antibody is applied in western blotting, immunohistochemistry, and flow cytometry. Western blotting confirms protein size, immunohistochemistry shows tissue localization, and flow cytometry quantifies expression on immune subsets. These methods make CD163L1 antibody useful in immunology and pathology research.
By providing validated CD163L1 antibody reagents,
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
