| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthetic peptide corresponding to a sequencein the middle region of human CDKN2C was used as the immunogen for the CDKN2C antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
CDKN2C Antibody / Cyclin-dependent kinase inhibitor 2C is a anti-CDKN2C Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.
Key elements and design rationale
- Target: CDKN2C
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB
Biological background
CDKN2C, also known as p18INK4C, is composed of ankyrin repeat domains that mediate specific binding to CDKs, thereby blocking their interaction with D-type cyclins. Through this inhibition, CDKN2C contributes to cell differentiation, growth arrest, and senescence. It is particularly active in hematopoietic, endocrine, and neural cells, where it coordinates cell cycle exit during differentiation.
The CDKN2C antibody is widely used in cancer biology, cell cycle regulation, and molecular pathology research to study proliferation control, checkpoint activation, and tumor suppression. Western blot analysis identifies a 19 kilodalton band corresponding to CDKN2C, while immunohistochemistry demonstrates nuclear staining in differentiated and quiescent cells. This antibody enables examination of INK4-mediated CDK inhibition and its effects on proliferation and differentiation pathways.
Loss or downregulation of CDKN2C is associated with multiple cancers, including glioma, pituitary adenoma, and leukemia, often through deletion or promoter methylation. Conversely, overexpression can contribute to cell cycle arrest and growth suppression. The CDKN2C antibody provides a dependable tool for studying tumor suppressor networks and checkpoint control.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
