| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived mouse Ceacam1 recombinant protein (Position: A34-D382) was used as the immunogen for the Ceacam1 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
Ceacam1 Antibody / Carcinoembryonic antigen-related cell adhesion molecule 1 is a anti-CEACAM1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Mouse, Rat.
Key elements and design rationale
- Target: CEACAM1
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, ICC, IF, FACS, ELISA
Biological background
CEACAM1 contributes to numerous physiological processes including tissue morphogenesis, angiogenesis, and modulation of inflammatory responses. Its expression at intercellular junctions facilitates homophilic and heterophilic interactions with other CEACAM family members, supporting epithelial integrity. In immune cells, CEACAM1 engagement downregulates T-cell activation and cytokine release, serving as a negative regulator of immune responses. Dysregulation of CEACAM1 signaling has been implicated in autoimmune disorders, infectious disease susceptibility, and tumor immune evasion. In cancer biology, CEACAM1 acts context-dependently: it may function as a tumor suppressor by maintaining epithelial polarity, yet also contributes to tumor metastasis and angiogenesis in certain malignancies.
The human CEACAM1 gene is located on chromosome 19q13.2 and spans over 9 exons. Its expression is transcriptionally controlled by cytokines such as interferon gamma and transforming growth factor beta, reflecting its integration into immune regulatory networks. Pathogen binding studies have shown that CEACAM1 serves as an entry receptor for several bacteria, including Neisseria species and Haemophilus influenzae, making it a target of interest in host-pathogen interaction research.
Immunohistochemical staining using CEACAM1 antibody demonstrates strong expression in liver, lung, and intestinal epithelia, with variable detection in tumors such as melanoma, colorectal carcinoma, and prostate cancer. CEACAM1 antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunofluorescence: visualize subcellular distribution and cell-to-cell heterogeneity.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
