| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | CKI-7 2HCl |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
CKI-7 (CAS 1177141-67-1) is a research-grade small molecule supplied by TargetMol.
Alternative names: CKI-7 2HCl
Physical Properties
| CAS Number | 1177141-67-1 |
|---|---|
| Molecular Formula | C11H14Cl3N3O2S |
| Molecular Weight | 358.67 g/mol |
| SMILES | O=S(C1=CC=C(Cl)C2=C1C=NC=C2)(NCCN)=O.(H)Cl.(H)Cl |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 uM; Ki: 8.5 uM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.
Target(s): S6 Kinase, ROCK, SGK, Casein Kinase, CDK
Signaling pathway(s): Cell Cycle/Checkpoint, MAPK, Metabolism, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Stem Cells
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Centrifuge the closed vial at 3000 rpm for 1–2 minutes to consolidate the powder at the bottom. For electrostatically charged powders, briefly warm the vial to room temperature and allow it to equilibrate before opening. Then add the appropriate solvent directly onto the powder and vortex before sonicating. Avoid tapping the vial vigorously, as this can generate fine powder aerosol.
It is not recommended to store DMSO stock solutions at room temperature. Once the stock solution is prepared, aliquot into single-use volumes and store at −20 °C (or −80 °C for sensitive compounds). Room-temperature storage accelerates chemical degradation and moisture uptake. When ready to use, thaw an aliquot at room temperature, use immediately, and avoid repeated freeze-thaw cycles.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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