| Field | Specification |
|---|---|
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| Accession Number | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide.
- Also known as: V102862
- CAS number: 181144-66-1
- Molecular formula: C14H12FN3O2.
- Purity: >96% (HPLC)
- Concentration: 0.1-200 μM
- Form: Lyophilized powder.
- Solubility: DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: NaV Na+ channels
- Source: Synthetic
- Activity: Co 102862 is a potent, broad spectrum and state-dependent blocker of neuronal voltage-gated Na+ channels that interacts selectively with inactivated states as opposed to resting states of the channel1. IC50 values are 0.28-15.9 µM in rat hippocampal neurons2. It is an anticonvulsant, demonstrating potent activity in rodent models of tonic/clonic and partial-complex seizures3.
- Alternative names: V102862
Peptide confirmation
Confirmed by amino acid analysis and mass spectrometry
Scientific background
Voltage-gated Na+ channels play key roles in determining neuronal excitability1,2. Voltage- and use-dependent blockage of voltage-gated Na+ channels appear to be important in the mechanism of action of many anticonvulsants (e.g. phenytoin (PHT), carbamazepine (CBZ) and lamotrigine (LTG)), local anesthetics (e.g. lidocaine and bupivacaine) and Class I antiarrhythmics3-10.Co 102862 is a potent, broad spectrum and state-dependent blocker of neuronal voltage-gated Na+ channels that interacts selectively with inactivated states as opposed to resting states of the channel11. IC50 values are 0.28-15.9 μM in rat hippocampal neurons11.Co 102862 is an anticonvulsant, demonstrating potent activity in rodent models of tonic/clonic and partial-complex seizures12.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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