| Field | Specification |
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| Host | |
| Immunogen | E.coli-derived human CTNNBL1 recombinant protein (Position: Q122-E231) was used as the immunogen for the CTNNBL1 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
CTNNBL1 Antibody / Catenin beta like 1 is a anti-CTNNBL1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.
Key elements and design rationale
- Target: CTNNBL1
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, FACS, ELISA
Biological background
Catenin beta like 1 contains armadillo (ARM) repeat domains that are structurally related to those in beta-catenin, but its function diverges toward nuclear events. Through these domains, CTNNBL1 associates with CDC5L, PRPF19, and additional splicing regulators, anchoring them within the spliceosomal complex. These interactions preserve accurate transcript maturation, prevent errors in gene expression, and safeguard the cell against the downstream consequences of mis-splicing. Because abnormal splicing can drive both oncogenesis and immune dysfunction, researchers frequently use CTNNBL1 antibody to map spliceosome activity and evaluate how this protein stabilizes nuclear machinery.
Recent studies have shown that Catenin beta like 1 is not limited to splicing but also functions in nuclear import pathways. CTNNBL1 assists in shuttling proteins that contain nuclear localization signals, ensuring that transcription factors and regulatory proteins reach the nucleus where they execute their functions. This process is fundamental for cell cycle regulation, DNA repair, and stress responses. When CTNNBL1 is disrupted, cells display impaired nuclear transport, altered gene expression, and reduced viability, underscoring its essential nature. With CTNNBL1 antibody, scientists can visualize these processes in detail using immunofluorescence, western blotting, and immunoprecipitation approaches.
Cancer biology has highlighted the importance of Catenin beta like 1. Abnormal expression of CTNNBL1 has been detected in colorectal cancer, breast cancer, and hematological malignancies, linking its function to tumor progression. Genetic polymorphisms in the CTNNBL1 gene have also been associated with autoimmune disease susceptibility and even with responses to viral infections. Researchers can therefore employ CTNNBL1 antibody to investigate how this nuclear factor contributes to disease risk, therapeutic response, and the molecular shifts that occur in malignancy. These insights are critical for understanding how dysregulated splicing and nuclear transport alter cell fate in pathological states.
The CTNNBL1 antibody offered by
Beyond cancer and immunity, CTNNBL1 has relevance in developmental biology. Proper splicing and nuclear transport are fundamental for embryogenesis, and disruption of CTNNBL1 can impair tissue growth and differentiation. Neurobiology research has also turned attention to CTNNBL1, as RNA processing errors are linked to neurodegenerative conditions such as amyotrophic lateral sclerosis and spinal muscular atrophy. By applying CTNNBL1 antibody in these areas, investigators can track how RNA maturation and nuclear protein import influence neural survival and function.
As more laboratories study the consequences of RNA dysregulation, CTNNBL1 antibody has become an indispensable reagent for connecting nuclear mechanics to cellular phenotypes. Its applications in cancer, autoimmunity, virology, and neurodegeneration research reflect the broad significance of Catenin beta like 1 in human biology. The antibody provided by
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
