| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | CYC116 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
CYC-116 (CAS 693228-63-6) is a research-grade small molecule supplied by TargetMol.
Alternative names: CYC116
Physical Properties
| CAS Number | 693228-63-6 |
|---|---|
| Molecular Formula | C18H20N6OS |
| Molecular Weight | 368.46 g/mol |
| SMILES | CC1=C(SC(N)=N1)C2=NC(NC3=CC=C(C=C3)N4CCOCC4)=NC=C2 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3alpha/beta, CK2, Plk1 and SAPK2A. Phase 1.
Target(s): S6 Kinase, Aurora Kinase, VEGFR, FLT, CDK
Signaling pathway(s): Chromatin/Epigenetic, Cell Cycle/Checkpoint, PI3K/Akt/mTOR signaling, Angiogenesis, MAPK, Tyrosine Kinase/Adaptors
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Most small molecule inhibitors are not compatible with autoclaving (121 °C), which can cause thermal decomposition or loss of biological activity. For sterile cell-based experiments, filter-sterilize working solutions through a 0.2 µm membrane after dilution into aqueous buffer. Verify thermal stability in the DataSheet before applying any heat treatment.
For small packages(1 mg, 5 mg, 10 mg, etc.）, it is not recommended to weigh them again which may lead to compound loss and inaccurate measurement. Our products are imported in their original packaging and accurately weighed, so you can directly dissolve the compound in the appropriate solvent upon receipt. For large packages, you can weigh and prepare stock solutions. It is recommended to start with at least 10 mg to reduce error. If conditions permit, you can first prepare a high-concentration stock solution and then aliquot it for use
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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equivalents, or discuss custom synthesis with the right QC documentation (RUO).
