| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | D-amino-5-phosphonopentaoic acid sodium salt |
| Cas No. | |
| Form | White solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 1 M NH4OH (50 mg/ml); water (9 mg/ml). |
| Source | Synthetic |
| Storage |
D-AP5.Na (D-(-)-2-Amino-5-phosphonopentanoic acid sodium salt) is a selective NMDA receptor antagonist that inhibits glutamate binding at the receptor site. NMDA receptors are critical for synaptic plasticity, learning, and memory, but their overactivation leads to excitotoxicity—a major contributor to neuronal death in neurodegenerative diseases such as Alzheimer’s, Huntington’s, and ALS. D-AP5.Na is widely used in neuroscience to study NMDA receptor-mediated signaling and to explore neuroprotective strategies by blocking calcium influx and excitotoxic damage. Its sodium salt form enhances solubility and stability for in vitro and in vivo applications.
Classification: Not WHMIS controlled.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
D-AP5.Na (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-412)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Schulte M., Roon R., Chalmers D., Sunter D., & Koerner J. (1994) Brain Res. 203-7.
