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Compound Overview
Dap-NE hydrochloride (CAS 2019182-02-4) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 2019182-02-4 |
|---|---|
| Molecular Formula | C18H29ClN2O3 |
| Molecular Weight | 356.89 g/mol |
| SMILES | Cl.CO(CH)((CH)(C)C(=O)N(CH)(C)(CH)(O)c1ccccc1)(CH)1CCCN1 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Dap-NE hydrochloride, a dipeptide hydrochloride and cleavable ADC linker, facilitates the synthesis of Antibody-Drug Conjugates (ADCs) by connecting antibody molecules to cytotoxins (1).
Target(s): ADC Linker, Others
Signaling pathway(s): Antibody-drug Conjugate/ADC Related, Others
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
When solubility is listed as < 1 mg/mL, the compound dissolves to less than 1 mg per milliliter in water at 25 °C, pH 7.4. Such compounds require an organic co-solvent such as DMSO to prepare a concentrated stock, which is then diluted into aqueous assay buffer. For cell-based assays, keep the final DMSO concentration below 0.1% (v/v) to avoid solvent-induced cytotoxicity.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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