DAPT

DAPT is a potent γ-secretase inhibitor widely used in neuroscience and neurodegenerative disease research. By selectively reducing the production of amyloid-β peptides Aβ40 and Aβ42—key contributors to Alzheimer’s disease pathology—DAPT serves as a critical tool for studying amyloidogenic processing of amyloid precursor protein (APP). It effectively lowers Aβ levels in human primary neuronal cultures and in vivo models, including brain, cerebrospinal fluid, and plasma, without altering non-amyloidogenic APPα and APPβ fragments. DAPT also inhibits Notch signaling, a pathway implicated in neural development and cell fate decisions. Its ability to promote neuronal differentiation makes it valuable for exploring neurogenesis and neural stem cell biology. DAPT is frequently cited in studies investigating the molecular mechanisms of Alzheimer’s disease, neuroinflammation, and synaptic dysfunction.

Classification: Caution: Substance not yet fully tested.

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

DAPT (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-378)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).