Decitabine

Decitabine is a DNA methyltransferase inhibitor that induces hypomethylation of DNA, leading to the reactivation of silenced genes. While primarily used as an antineoplastic agent in hematologic malignancies, its epigenetic modulation capabilities have implications in neuroscience. Decitabine has been shown to enhance neuronal plasticity, promote neurogenesis, and influence memory-related gene expression. These properties make it a valuable compound for exploring the role of DNA methylation in neurodevelopmental and neurodegenerative disorders. Its ability to modulate gene expression without altering the DNA sequence positions Decitabine as a powerful tool in epigenetic research related to brain function and disease.

Classification: Harmful – May be harmful if inhaled, swallowed or absorbed through skin.

Safety Phrases:

• S22 - Do not breathe dust
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• S24/25- Avoid contact with skin and eyes

Hazard Statements:

• H341 – Suspected of causing genetic defects
• H360 – May damage fertility or the unborn child

Precautionary Statements:

• P280 – Wear protective gloves/protective clothing/ eye protection/ face protection
• P308+313 – If exposed or concerned: Get Medical Advise/Attention

Decitabine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-352)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).