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| Molecular Weight | |
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| Target |
Compound Overview
DETQ (CAS 1638667-81-8) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 1638667-81-8 |
|---|---|
| Molecular Formula | C22H25Cl2NO3 |
| Molecular Weight | 422.34 g/mol |
| SMILES | C(CH)1N((CH)(CO)Cc2c1cccc2C(C)(C)O)C(=O)Cc1c(Cl)cccc1Cl |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
DETQ, a selective, allosteric, and orally active potentiator of the dopamine D1 receptor (Dopamine Receptor), enhances cAMP production in HEK293 cells expressing the human D1 receptor, achieving an EC50 of 5.8 nM and a K b of 26 nM. It demonstrates approximately 30-fold reduced potency at rat and mouse D1 receptors and shows no activity at the human D5 receptor (1).
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
The structure of compounds is confirmed through HNMR and purity is verified through HPLC or LCMS, with most compounds having a purity of over 98%. Each batch comes with a Certificate of Analysis (COA), and testing reports are also displayed on our official website.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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