Dofetilide

Dofetilide is a class III antiarrhythmic agent that selectively blocks the rapid component of the delayed rectifier potassium current. While primarily used in cardiology, its effects on potassium channels have relevance in neuroscience, particularly in studies of neuronal excitability and ion channel pharmacology. Understanding how dofetilide modulates potassium currents can inform research on seizure activity, neuroprotection, and the electrophysiological properties of neurons.

Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.

Safety Phrases:

• S22 - Do not breathe dust
• S24/25 - Avoid contact with skin and eyes
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• S53 - Avoid exposure - obtain special instruction before use
• S57 - Use appropriate containment to avoid environmental contamination

Risk Phrases:

• R22 - Harmful if swallowed
• R48 - Danger of serious damage to health by prolonged exposure
• R51/53 - Toxic to aquatic organisms, may cause longterm adverse effects in the aquatic environment
• R61 - May cause harm to the unborn child
• R62 - Possible risk of impaired fertility

Hazard Phrases:

H302-H319-H360

Precautionary Phrases:

P201-P305 + P351 + P338-P308 + P313

Dofetilide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-311)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).