| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Dovitinib Lactate |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Dovitinib lactate hydrate (CAS 915769-50-5) is a research-grade small molecule supplied by TargetMol.
Alternative names: Dovitinib Lactate
Physical Properties
| CAS Number | 915769-50-5 |
|---|---|
| Molecular Formula | C24H27FN6O4 |
| Molecular Weight | 482.51 g/mol |
| SMILES | O.CC(O)C(O)=O.CN1CCN(CC1)c1ccc2nc((nH)c2c1)-c1c(N)c2c(F)cccc2(nH)c1=O |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.
Target(s): c-Kit, PDGFR, VEGFR, FLT, FGFR
Signaling pathway(s): Angiogenesis, Tyrosine Kinase/Adaptors
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Centrifuge the closed vial at 3000 rpm for 1–2 minutes to consolidate the powder at the bottom. For electrostatically charged powders, briefly warm the vial to room temperature and allow it to equilibrate before opening. Then add the appropriate solvent directly onto the powder and vortex before sonicating. Avoid tapping the vial vigorously, as this can generate fine powder aerosol.
Use a bath-type ultrasonic cleaner rather than a high-intensity ultrasonic disruptor. Bath sonicators provide gentle, uniform agitation appropriate for dissolving solid compounds without generating cavitation damage or excessive heat. Ensure the solvent tube is fully submerged and use short sonication pulses of 5–10 seconds.
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- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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