| Field | Specification |
|---|---|
| Alternative names | Adriamycin |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C27H29NO11•HCl |
| Purity | |
| Bioactivity | Inducer |
| Activity | |
| Solubility | May be dissolved in water (25 mg/ml); or DMSO (30 mg/ml) |
| SMILES | |
| InChIKey | |
| Form | Red-Orange powder |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Doxorubicin Hydrochloride is a DNA-intercalating chemotherapeutic agent known for its broad-spectrum anticancer activity. In neuroscience, Doxorubicin is used to model neurotoxicity and investigate mechanisms of neuronal damage, particularly in studies of chemotherapy-induced cognitive impairment ("chemo brain"). It induces apoptosis by inhibiting topoisomerase II and disrupting DNA replication and transcription. Doxorubicin also triggers oxidative stress and mitochondrial dysfunction—key features of neurodegenerative diseases. Although its clinical use is limited by systemic toxicity, including hematologic and cardiac effects, its ability to induce autophagy and cell death pathways makes it a valuable tool for studying neuronal stress responses and neurodegeneration in vitro and in vivo.
Classification: Not WHMIS controlled.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H302- Harmful if swallowed.
- H350- May cause cancer.
Precautionary statements:
- P201- Obtain special instructions before use.
- P308 + P313- IF exposed or concerned: Get medical advice/ attention.
Doxorubicin Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-390)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Chen, N. T. et al. (2012). PLoS One. 7(9).
3. Patel, S. et al. (1997). Mol Pharmacol. 52(4): 658-66.
4. Cutts, S. et al. (1996). J Biol Chem. 271(10): 5422-9.
5. Danesi, R. et al. (2004). Transplant Proc. 36(3): 703-4.
6. Dirks-Naylor, A. (2013). Life Sci. 93(24): 913-6.
