| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human Desmocollin 1 was used as the immunogen for the DSC1 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
DSC1 Antibody / Desmocollin 1 is a anti-DSC1 Rabbit antibody Recombinant Rabbit Monoclonal clone 31D56 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: DSC1
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 31D56, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
Desmocollin 1 is a transmembrane protein that interacts with desmogleins, plakoglobin, and desmoplakin to form stable desmosomal junctions. Research using DSC1 antibody has shown that it is expressed predominantly in stratified squamous epithelia, where it contributes to strong intercellular adhesion. This adhesion maintains tissue integrity under mechanical stress, particularly in the skin and mucosal surfaces.
Studies with DSC1 antibody have revealed that Desmocollin 1 exists in multiple isoforms generated by alternative splicing. These isoforms contribute to structural diversity within desmosomes and enable fine-tuning of adhesive strength. Regulation of isoform expression is developmentally controlled and varies between epithelial layers, suggesting specialized functions for different Desmocollin 1 variants.
Dysregulation of Desmocollin 1 is linked to disease. Research using DSC1 antibody has demonstrated that mutations in DSC1 cause striate palmoplantar keratoderma, a skin disorder characterized by thickening of the palms and soles. Autoantibodies against Desmocollin 1 are found in autoimmune skin diseases such as pemphigus. Loss of Desmocollin 1 expression has also been reported in cancers, where reduced adhesion facilitates invasion and metastasis. These findings highlight the importance of DSC1 in health and disease.
Desmocollin 1 also contributes to barrier function. Studies with DSC1 antibody have shown that intact desmosomal adhesion prevents pathogen invasion and regulates paracellular permeability. This function underscores the role of Desmocollin 1 not only in mechanical integrity but also in defense and tissue homeostasis.
DSC1 antibody is commonly applied in immunohistochemistry, immunofluorescence, and western blotting. Immunohistochemistry highlights localization in epithelial layers, immunofluorescence reveals colocalization with other desmosomal proteins at junctions, and western blotting detects isoform expression. These applications make DSC1 antibody essential for adhesion biology and pathology research.
By providing validated DSC1 antibody reagents,
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
