| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| Target |
Compound Overview
EGFR-IN-84 is a research-grade small molecule supplied by TargetMol.
Physical Properties
| Molecular Formula | C25H20N6O3S2 |
|---|---|
| Molecular Weight | 516.59 g/mol |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
EGFR-IN-84 (Compound 6g), an EGFR inhibitor with an IC50 of 24 nM, impedes the growth of A549 cells with an IC50 value of 1.537 uM and is utilized for lung cancer research (1).
Target(s): EGFR
Signaling pathway(s): Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Sonication time depends on compound solubility and concentration. In most cases, 1–3 minutes of intermittent bath sonication is sufficient to dissolve small molecule compounds in DMSO. For poorly soluble compounds, warming the solvent to 37–50 °C combined with brief vortexing between sonication pulses can improve dissolution. If the compound remains undissolved, prepare a more dilute stock solution.
Yes — TargetMol inhibitors can be used in cell-based and in vitro experiments. Prepare a DMSO stock, then dilute into cell culture medium to the desired working concentration, keeping DMSO ≤ 0.1% (v/v) to avoid solvent toxicity. Note that not all compounds have published data for every cell line or assay system; in such cases, perform a dose-response experiment with appropriate positive and vehicle controls to validate efficacy in your specific model.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
