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| Target |
Compound Overview
Epiblastin A (CAS 16470-02-3) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 16470-02-3 |
|---|---|
| Molecular Formula | C12H10ClN7 |
| Molecular Weight | 287.71 g/mol |
| SMILES | NC=1C2=C(N=C(N)C(=N2)C3=CC(Cl)=CC=C3)N=C(N)N1 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Epiblastin A is an inhibitor of Casein Kinase 1 (CK1). Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs).
Target(s): Casein Kinase
Signaling pathway(s): Metabolism, Stem Cells
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Most small molecule inhibitors are not compatible with autoclaving (121 °C), which can cause thermal decomposition or loss of biological activity. For sterile cell-based experiments, filter-sterilize working solutions through a 0.2 µm membrane after dilution into aqueous buffer. Verify thermal stability in the DataSheet before applying any heat treatment.
Centrifuge the closed vial at 3000 rpm for 1–2 minutes to consolidate the powder at the bottom. For electrostatically charged powders, briefly warm the vial to room temperature and allow it to equilibrate before opening. Then add the appropriate solvent directly onto the powder and vortex before sonicating. Avoid tapping the vial vigorously, as this can generate fine powder aerosol.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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