| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human EURL recombinant protein (Position: D26-N297) was used as the immunogen for the EURL antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
EURL Antibody / Expressed in undifferentiated retina and lens / C21orf91 is a anti-EURL Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: EURL
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, FACS, ELISA
Biological background
Functionally, EURL antibody identifies a 250-amino-acid cytoplasmic protein that interacts with components of the microtubule and actin cytoskeleton to influence cell shape and division. EURL expression is enriched in neural precursor cells, where it controls neuronal lineage specification and cortical development. It also supports early lens and retinal formation during embryogenesis.
The EURL gene is located on chromosome 21q22.12, within the Down syndrome critical region. Its expression in the developing brain suggests a role in cortical layering and synaptic maturation. EURL may also contribute to dosage-sensitive developmental pathways affected by trisomy 21.
Pathologically, altered EURL expression has been associated with neurodevelopmental delay and Down syndrome-related brain abnormalities. Dysregulation affects neuronal migration and axon guidance, leading to impaired neural circuit formation. Research using EURL antibody supports studies in brain development, neurogenetics, and cytoskeletal dynamics.
EURL antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect neural differentiation markers.
Structurally, C21orf91 protein contains conserved helical motifs that mediate cytoskeletal binding and spatial organization within developing neurons. This antibody enables analysis of EURL's role in neuronal specification and brain morphogenesis.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
