| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| Target |
Compound Overview
FEN1-IN-7 (CAS 824983-90-6) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 824983-90-6 |
|---|---|
| Molecular Formula | C16H14N2O6S |
| Molecular Weight | 362.36 g/mol |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
FEN1-IN-7 (compound 16), a selective Flap endonuclease-1 (FEN1) inhibitor with an IC50 of 18 nM, plays a role in DNA damage repair in mammalian cells. Additionally, it targets the related endonuclease, xeroderma pigmentosum G (XPG), with an IC50 of 3.04 uM. FEN1-IN-7 enhances the sensitivity of cancer cells to potent DNA alkylating or methylating agents (1).
Target(s): FLAP
Signaling pathway(s): Immunology/Inflammation
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Most small molecule inhibitors are not compatible with autoclaving (121 °C), which can cause thermal decomposition or loss of biological activity. For sterile cell-based experiments, filter-sterilize working solutions through a 0.2 µm membrane after dilution into aqueous buffer. Verify thermal stability in the DataSheet before applying any heat treatment.
For currently available products, batch-specific purity data (HPLC chromatogram, NMR spectrum, and Certificate of Analysis) is accessible via the DataSheet link on the product page. For future or custom synthesis products, purity determination is conducted upon availability and published on the product page. Contact BioHippo for batch-specific CoA requests or custom synthesis enquiries.
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