| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | FzM-1 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
FzM1 (CAS 1680196-54-6) is a research-grade small molecule supplied by TargetMol.
Alternative names: FzM-1
Physical Properties
| CAS Number | 1680196-54-6 |
|---|---|
| Molecular Formula | C21H16N2O2S |
| Molecular Weight | 360.43 g/mol |
| SMILES | N(C(NC1=CC2=C(C=C1)C=CC=C2)=O)C=3C=C(C=C(O)C3)C4=CC=CS4 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=?6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/beta-catenin signaling pathway.
Target(s): Wnt/beta-catenin
Signaling pathway(s): Cytoskeletal Signaling, Stem Cells
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
After the stock solution is prepared, it is typically stored at -80°C and can be kept for over 1 year. It is recommended to aliquot to avoid repeated freeze-thaw cycles. For frequent use, it can be stored at 4°C for over a week.
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