| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human GAS2 was used as the immunogen for the GAS2 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
GAS2 Antibody / Growth arrest specific protein 2 is a anti-GAS2 Rabbit antibody Recombinant Rabbit Monoclonal clone 31G23 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human.
Key elements and design rationale
- Target: GAS2
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 31G23, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB, IHC
Biological background
Growth arrest specific protein 2 contains actin binding domains and microtubule binding motifs that allow it to crosslink cytoskeletal components. Research using GAS2 antibody has demonstrated that it stabilizes actin filaments and microtubules during cell cycle arrest, contributing to maintenance of cell shape and integrity. By coordinating cytoskeletal structures, GAS2 helps control cell migration, adhesion, and survival.
In addition to cytoskeletal regulation, GAS2 is involved in apoptosis. Studies with GAS2 antibody have shown that it is cleaved by caspases during programmed cell death, producing fragments that promote cytoskeletal disassembly. This links GAS2 function to apoptotic morphology, including cell shrinkage and membrane blebbing. Dysregulation of GAS2 expression or cleavage contributes to abnormal cell survival in disease.
GAS2 has been studied in cancer, where its expression influences cell proliferation and migration. Research with GAS2 antibody has indicated that altered levels promote tumor progression by disrupting cytoskeletal control. Conversely, in some contexts GAS2 expression suppresses tumorigenesis by stabilizing growth arrest. This duality highlights its complex roles depending on cellular environment.
GAS2 antibody is used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects full length and cleaved forms, immunohistochemistry shows distribution in growth arrested tissues, and immunofluorescence reveals colocalization with actin and tubulin. These applications make GAS2 antibody valuable in studies of cell cycle, cytoskeletal dynamics, and apoptosis.
By providing validated GAS2 antibody reagents,
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
