| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human GAS2L2 recombinant protein (Position: R43-R829) was used as the immunogen for the GAS2L2 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
GAS2L2 Antibody / Growth arrest-specific protein 2-like 2 is a anti-GAS2L2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.
Key elements and design rationale
- Target: GAS2L2
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, ELISA
Biological background
GAS2L2 is encoded by the GAS2L2 gene on human chromosome 17p13.1. The protein is approximately 97 kilodaltons and contains a calponin homology (CH) domain that binds actin and a GAS2-related (GAR) domain that associates with microtubules. This dual-binding capability enables GAS2L2 to coordinate actin-microtubule crosslinking, influencing cell architecture and mechanotransduction.
The GAS2L2 antibody reveals filamentous and junctional staining in epithelial and smooth muscle cells. GAS2L2 expression is enriched in respiratory and reproductive epithelia, where it stabilizes apical cell-cell contacts. Loss of GAS2L2 disrupts ciliogenesis and planar cell polarity, leading to impaired epithelial alignment and fluid transport. In fibroblasts and neurons, GAS2L2 contributes to microtubule organization and axonal guidance.
Beyond structural support, GAS2L2 regulates cell migration and wound healing by modulating actin polymerization dynamics. It interacts with signaling proteins that respond to mechanical stress, suggesting a role in tissue homeostasis and mechanosensitive pathways. Mutations or altered expression of GAS2L2 are associated with ciliary dysfunction and airway remodeling disorders.
Because of its crosslinking function, GAS2L2 serves as a molecular bridge between cytoskeletal networks, coordinating force generation and cellular tension.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
