| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Natural |
| Storage | |
| Target |
Product details
- Chemical name: ((1R,3R,6R,7S,8S,10R,11R,12R,13S,16S,17R)-8-tert-butyl-6,12,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,15,18-trione.
- CAS number: 15291-77-7
- Molecular formula: C20H24O10.
- Purity: >98%
- Concentration: 500-1000 µM.
- Form: Lyophilized powder.
- Solubility: 200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: 200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: 5-HT3A receptors
- Source: Natural
- Activity: Ginkgolide B is a 5-HT3A channel blocker1.
Scientific background
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.Ginkgolide B is a natural non-selective blocker of 5-HT3A channel. Ginkgolide is extracted from the leaves, roots and bark of the tree Ginkgo biloba. Ginkgolide B has an effective concentration of 500-1000 μM and an IC50 of 730 μM for the 5-HT3A receptor and an IC50 of 3.9 mM for the 5-HT3B receptor thus enabling discrimination between the two. Ginkgolide also binds to anion Cys-loop receptors such as GABA and glycine receptors. Ginkgolide does not displace the specific 5-HT3 receptor antagonist granisetron, thus confirming that it does not act at the agonist binding site. In addition, inhibition by Ginkgolide at 5-HT3A receptors is weakly use-dependent, and recovery of the receptor is also activity dependent, indicating channel block as the mechanism of inhibition. Ginkgolide is widely used in traditional medicine and has a wide spectrum of beneficial properties such as anti-convulsion, neuro-protection and reducing anxiety2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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