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Compound Overview
Gly-Cyclopropane-Exatecan (CAS 2414254-49-0) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 2414254-49-0 |
|---|---|
| Molecular Formula | C32H34FN5O7 |
| Molecular Weight | 619.64 g/mol |
| SMILES | CC(C)1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC(CH)(NC(=O)C(OCNC(=O)CN)C6CC… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Gly-Cyclopropane-Exatecan, a DNA Topoisomerase I inhibitor containing Exatecan, is key in synthesizing the anti-B7-H4 ADC, specifically the ADC hu2F7-Exatecan (compound 34). This compound demonstrated antitumor activity both in vivo and in vitro (1).
Target(s): Others, ADC Cytotoxin
Signaling pathway(s): Antibody-drug Conjugate/ADC Related, Others
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
It is not recommended to store DMSO stock solutions at room temperature. Once the stock solution is prepared, aliquot into single-use volumes and store at −20 °C (or −80 °C for sensitive compounds). Room-temperature storage accelerates chemical degradation and moisture uptake. When ready to use, thaw an aliquot at room temperature, use immediately, and avoid repeated freeze-thaw cycles.
The structure of compounds is confirmed through HNMR and purity is verified through HPLC or LCMS, with most compounds having a purity of over 98%. Each batch comes with a Certificate of Analysis (COA), and testing reports are also displayed on our official website.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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