| Field | Specification |
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| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of mouse GSTM2 was used as the immunogen for the GSTM2 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
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| Target | |
| UniProt # |
Overview
GSTM2 Antibody / Glutathione S-transferase Mu 2 is a anti-GSTM2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Mouse, Rat. Reported localization: Cytoplasm.
Key elements and design rationale
- Target: GSTM2
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, IHC
Biological background
Structurally, GSTM2 forms homodimers, each monomer containing an N-terminal glutathione-binding site (G-site) and a C-terminal hydrophobic substrate-binding site (H-site). This configuration enables GSTM2 to catalyze the conjugation of reduced glutathione (GSH) to electrophilic substrates, rendering them more water-soluble for excretion. GSTM2 also exhibits peroxidase activity, neutralizing reactive oxygen species and maintaining cellular redox balance.
The GSTM2 antibody is widely used in toxicology, pharmacology, and metabolic research to study oxidative stress responses, detoxification pathways, and enzyme induction mechanisms. Western blot analysis identifies a 26 kilodalton band corresponding to GSTM2, while immunohistochemistry reveals strong cytoplasmic staining in hepatocytes and renal tubular cells. This antibody supports investigations into tissue-specific detoxification and metabolic adaptation to stress and xenobiotics.
Genetic polymorphisms in GSTM2 and related GST genes influence susceptibility to environmental toxins, carcinogens, and drug-induced injury. Reduced expression or functional loss of GSTM2 increases oxidative damage and contributes to disorders such as asthma, cancer, and neurodegenerative disease. Conversely, elevated expression is associated with chemoresistance and altered drug metabolism in tumor cells. The GSTM2 antibody provides a reliable tool for quantifying enzyme expression and understanding its contribution to cellular defense systems.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
