| Field | Specification |
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| Target | |
| Alternative names | BCNG-1, BCNG1, Brain cyclic nucleotide gated channel 1, Brain cyclic nucleotide-gated channel 1, HAC2, HCN1, HCN1_HUMAN, Hyperpolarization activated cyclic nucleotide gated potassium channel 1, Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
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| Immunogen | Fusion protein amino acids 778-910 (C terminus) of rat HCN1 (Q9JKB0 sequence version 1) |
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Hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) is a voltage-gated ion channel that contributes to the generation and regulation of rhythmic electrical activity in neurons. It is predominantly expressed in the cortex, hippocampus, and cerebellum—regions critically involved in cognition, memory, and motor control.
HCN1 channels play a key role in setting the resting membrane potential and modulating synaptic integration and neuronal excitability. In neurodegenerative diseases, such as Alzheimer’s and epilepsy-related cognitive decline, dysregulation of HCN1 expression or function has been linked to impaired synaptic plasticity and network dysfunction.
Altered HCN1 activity can disrupt the balance of excitatory and inhibitory signaling, contributing to neuronal hyperexcitability and excitotoxicity—both of which are implicated in neurodegeneration. Moreover, HCN1 has been shown to influence dendritic integration and long-term potentiation (LTP), processes essential for learning and memory.
Given its role in maintaining neuronal homeostasis and circuit stability, HCN1 is emerging as a potential therapeutic target for modulating brain excitability and protecting against neurodegenerative progression.
1 µg/ml of SMC-304 was sufficient for detection of HCN1 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-304D — Size: 100 ug: HCN1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-304D, RRID: AB_2279461)
- SMC-304D-A390 — Size: 100 ug: HCN1 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-304D-A390, RRID: AB_2700074)
- SMC-304D-A488 — Size: 100 ug: HCN1 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-304D-A488, RRID: AB_2700075)
- SMC-304D-A594 — Size: 100 ug: HCN1 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-304D-A594, RRID: AB_2700077)
- SMC-304D-APC — Size: 100 ug: HCN1 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-304D-APC, RRID: AB_2700083)
- SMC-304D-BI — Size: 100 ug: HCN1 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-304D-BI, RRID: AB_2700084)
- SMC-304D-FITC — Size: 100 ug: HCN1 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-304D-FITC, RRID: AB_2700085)
- SMC-304D-HRP — Size: 100 ug: HCN1 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-304D-HRP, RRID: AB_2700086)
- SMC-304D-PCP — Size: 100 ug: HCN1 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-304D-PCP, RRID: AB_2700088)
- SMC-304D-RPE — Size: 100 ug: HCN1 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-304D-RPE, RRID: AB_2700089)
- SMC-304S — Size: 12 ug: HCN1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-304S, RRID: AB_2279461)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
