| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | [(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate |
| Cas No. | |
| Form | Yellow Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml) |
| Source | Synthetic |
| Storage |
Herbimycin A is a benzoquinoid ansamycin antibiotic known for its irreversible inhibition of tyrosine kinases through thiol group interaction. While predominantly studied in oncology, Herbimycin A’s ability to modulate kinase signaling cascades positions it as a candidate for neurodegenerative disease research. Tyrosine kinases play critical roles in neuronal survival, synaptic plasticity, and neuroinflammation. By inhibiting kinases such as Src and Abl, Herbimycin A may help attenuate aberrant signaling associated with neurodegenerative conditions. Its potential to influence phospholipase C activity and downstream pathways further supports its relevance in neuroscience, particularly in the context of cellular stress responses and neuroprotection.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Herbimycin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-116)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Fukazawa H., et al. (1991) Biochem. Pharmacol. 42: 1661.
3. Satoh T., et al. (1992) J.Biol.Chem. 267: 2537.
4. Weiss R., and Nuccitelli R. (1992) J.Biol.Chem. 267:5608.
