| Field | Specification |
|---|---|
| Target | |
| Alternative names | HSPA1A, HSPA1B, HSPA1, HSPA8, HSP70, HSP70-1, HSP70.1, HSP70-2, HSP72, HSP73, HSC70, HSX70, Heat shock 70 kDa protein 1A, Heat shock 70 kDa protein 1B, Heat shock 70 kDa protein 8, Heat shock cognate 71 kDa protein |
| Accession number | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Human Recombinant HSP70/HSC70 |
| Purification | |
| Cellular localization | |
| Concentration | |
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| Shipping | |
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HSP70 proteins are a highly conserved family of 70-kDa molecular chaperones essential for maintaining protein homeostasis across all domains of life. In eukaryotes, HSP70 genes form a multigene family, with isoforms localized to the cytosol, nucleus, mitochondria, endoplasmic reticulum, and chloroplasts. These chaperones are either constitutively expressed (HSC70) or stress-inducible (HSP70), and share over 50% sequence identity across species.
Functionally, HSP70s bind ATP with high affinity and exhibit ATPase activity that is stimulated by interaction with unfolded or misfolded proteins. The N-terminal domain mediates ATP binding, while the C-terminal domain is responsible for substrate recognition. This ATP-driven cycle enables HSP70s to bind and release hydrophobic regions of nascent or damaged proteins, preventing aggregation and facilitating proper folding, transport, and assembly.
In neuroscience, HSP70 and HSC70 are critical for neuronal survival under proteotoxic stress—conditions commonly associated with neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. These chaperones stabilize misfolded proteins, support autophagic clearance, and modulate apoptotic signaling pathways. Their ability to interact with co-chaperones and degradation machinery further enhances their role in maintaining neuronal proteostasis.
Given their central role in stress response and protein quality control, HSP70/HSC70 are promising therapeutic targets and biomarkers in neurodegeneration research.
1 µg/ml of SMC-104 was sufficient for detection of HSP70/HSC70 in 20 µg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-104B — Size: 200 ug: HSP70/HSC70 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-104B, RRID: AB_2120301)
- SMC-104B-A390 — Size: 200 ug: HSP70/HSC70 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-104B-A390, RRID: AB_2697819)
- SMC-104B-A488 — Size: 200 ug: HSP70/HSC70 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-104B-A488, RRID: AB_2697820)
- SMC-104B-A594 — Size: 200 ug: HSP70/HSC70 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-104B-A594, RRID: AB_2697822)
- SMC-104B-APC — Size: 200 ug: HSP70/HSC70 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-104B-APC, RRID: AB_2697828)
- SMC-104B-BI — Size: 200 ug: HSP70/HSC70 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-104B-BI, RRID: AB_2697829)
- SMC-104B-FITC — Size: 200 ug: HSP70/HSC70 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-104B-FITC, RRID: AB_2697830)
- SMC-104B-HRP — Size: 200 ug: HSP70/HSC70 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-104B-HRP, RRID: AB_2697831)
- SMC-104B-PCP — Size: 200 ug: HSP70/HSC70 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-104B-PCP, RRID: AB_2697833)
- SMC-104B-RPE — Size: 200 ug: HSP70/HSC70 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-104B-RPE, RRID: AB_2697834)
- SMC-104S — Size: 12 ug: HSP70/HSC70 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-104S, RRID: AB_2120301)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
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