Huperzine A

Huperzine A is a naturally occurring alkaloid and potent reversible inhibitor of acetylcholinesterase. It enhances cholinergic transmission by preventing the breakdown of acetylcholine, a neurotransmitter critical for learning and memory. In neurodegenerative disease research, Huperzine A has shown promise in improving cognitive function and reducing neurotoxicity in models of Alzheimer’s disease. It also exhibits antioxidant and neuroprotective effects, making it a candidate for therapeutic development in age-related cognitive decline and neurodegeneration.

Classification: Toxic

Safety Phrases:

• S22 - Do not breathe dust
• S24/25 - Avoid contact with skin and eyes
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Hazard Phrases:

• H301+ H311 +H331 – Toxic if swallowed, in contact with skin or inhaled
• H315 - Causes skin irritation.
• H319 - Causes serious eye irritation.
• H335 - May cause respiratory irritation.

Precautionary Phrases:

• P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.
• P280 - Wear protective gloves/protective clothing.
• P301+ P310 – IF SWALLOWED: Immediately call POISON CENTER or doctor/physician.
• P305+ P351+ P338 – IF IN EYES: rinse cautiously with water for several minutes. If wearing contact lenses remove them and continue to rinse.
• P311 – call a POISON CENTER or doctor/physician

Huperzine A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-365)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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