| Field | Specification |
|---|---|
| Alternative names | (1R,9S,13E)- 1-Amino- 13-ethylidene- 11-methyl- 6-azatricyclo[7.3.1.02,7] trideca- 2(7),3,10- trien- 5-one |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C15H18N2O |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in DMSO, methanol or ethanol. |
| SMILES | |
| InChIKey | |
| Form | Off-White solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Huperzine A is a naturally occurring alkaloid and potent reversible inhibitor of acetylcholinesterase. It enhances cholinergic transmission by preventing the breakdown of acetylcholine, a neurotransmitter critical for learning and memory. In neurodegenerative disease research, Huperzine A has shown promise in improving cognitive function and reducing neurotoxicity in models of Alzheimer’s disease. It also exhibits antioxidant and neuroprotective effects, making it a candidate for therapeutic development in age-related cognitive decline and neurodegeneration.
Classification: Toxic
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
- H301+ H311 +H331 – Toxic if swallowed, in contact with skin or inhaled
- H315 - Causes skin irritation.
- H319 - Causes serious eye irritation.
- H335 - May cause respiratory irritation.
Precautionary Phrases:
- P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.
- P280 - Wear protective gloves/protective clothing.
- P301+ P310 – IF SWALLOWED: Immediately call POISON CENTER or doctor/physician.
- P305+ P351+ P338 – IF IN EYES: rinse cautiously with water for several minutes. If wearing contact lenses remove them and continue to rinse.
- P311 – call a POISON CENTER or doctor/physician
Huperzine A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-365)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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2. Tang L., Wang r., Tang x., (2005) Acta Acta Pharmacologica 26(6): 673-678.
3. Ved Hs,. Koenig ml., Dave JR., Doctor BP.(1997) Neurorport. 8(4): 963-8.
4. Li WM., Kan KK., Carlier PR., Pang YP., Han YF. YF., (2007) Curr Alzheimer Res. 4: 386-396.
