| Field | Specification |
|---|---|
| Target | |
| Alternative names | Interleukin-17A (IL-17, IL-17A)|Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8)|IL17A|CTLA8|IL17 |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | interleukin 17A |
| Conjugate | |
| Molecular weight | |
| Purity | |
| Purification | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Scientific Background
IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2(PTGS2/COX-2), as well as enhance the production of nitric oxide(NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.
Product Overview
This monoclonal antibody (clone 5E2), raised in Mouse, recognizes IL17A. It is validated for ELISA, Western Blot, Flow Cytometry.
Validated Applications
| Applications | ELISA, Western Blot, Flow Cytometry |
|---|---|
| WB | 1:500-1:1000 |
Optimal dilutions should be determined by the end user for each application and sample type.
Immunogen
interleukin 17A
Specifications
| Host | Mouse |
|---|---|
| Clonality | Monoclonal |
| Clone | 5E2 |
| Isotype | IgG1 |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Immunogen | interleukin 17A |
| Purification | Protein A+G Purification |
| Purity | ≥95% as determined by SDS-PAGE |
| Form | Liquid |
| Target MW | 18 kDa |
| UniProt # | Q16552 |
| Gene ID | 3605 |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Alternative Names | Interleukin-17A (IL-17, IL-17A)|Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8)|IL17A|CTLA8|IL17 |
Reactivity Notes
Validated reactivity: Human. For other species, epitope conservation may allow cross-reactivity; confirm with appropriate controls.
Safety & Handling
This product is for research use only (RUO) and is not intended for diagnostic or therapeutic use. The formulation contains sodium azide; handle with standard laboratory precautions.
Related Products
Explore related antibodies and reagents for IL17A research from Fine Test, or contact us for alternative formats.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
