| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 1-[1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-pyrrolidin-1-yl-ethanone |
| Cas No. | |
| Form | Beige Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 30 mg/ml DMSO, 15 mg/ml Ethanol |
| Source | Synthetic |
| Storage |
IU1 is a selective inhibitor of the deubiquitinating enzyme Usp14, enhancing proteasome activity and substrate proteolysis. In neurodegenerative disease research, IU1 is utilized to promote clearance of misfolded proteins, supporting studies on proteostasis and therapeutic strategies aimed at reducing toxic protein aggregates in neural cells.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Hazard Statements:
- H303 – May be harmful if swallowed
- H318 – Causes serious eye damage
Precautionary Statements:
- P280 – Wear protective gloves/ eye protection/ face protection
- P305 + P351 + P338 – If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses.
IU1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-329)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Lee B.H., et al. (2010) Mol. Cell. Proteomics 10: R1100003871.
