| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 4-cyclopropyl-5-(pyridin-4-yl)pyrimidin-2-amine |
| Form | White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in CDCI3 |
| Source | Synthetic |
| Storage |
J9 is a small molecule that enhances glucocorticoid receptor expression, thereby sensitizing T-cell acute lymphoblastic leukemia (T-ALL) cells to dexamethasone. While primarily studied in oncology, its mechanism of modulating steroid receptor pathways may have implications in neuroinflammation and stress-related neural disorders. Glucocorticoid signaling plays a role in brain function and resilience to stress, suggesting that J9 could be explored for its potential to modulate neuroendocrine responses in psychiatric and neurodegenerative conditions.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
J9 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-182)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
