| Field | Specification |
|---|---|
| Alternative names | 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C21H25NO2S |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in DMSO (20 mg/ml) or ethanol (10 mg/ml) |
| SMILES | |
| InChIKey | |
| Form | Off-white solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
JX 401 is a potent and reversible inhibitor of p38α mitogen-activated protein kinase (MAPK), a key regulator of inflammatory responses and cellular stress signaling. In neurodegenerative disease research, p38α MAPK is implicated in microglial activation, cytokine production, and neuronal apoptosis. JX 401 is used to investigate the role of p38α in neuroinflammation and neurotoxicity, particularly in models of Alzheimer's disease, Parkinson's disease, and traumatic brain injury. Its cell-permeable nature and specificity make it a valuable tool for dissecting MAPK signaling pathways in the central nervous system.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
JX 401 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-454)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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