| Field | Specification |
|---|---|
| Mfr No | |
| Accession Number | |
| Alternative Names | Kir6.1, KCNJ8, Kcnj8, Inward rectifier K(+) channel Kir6.1, Potassium channel inwardly rectifying subfamily J member 8, ATP-sensitive inward rectifier potassium channel 8, uKATP-1 |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1 |
| Isotype | |
| Product Type | |
| Reactivity | |
| Shipping | |
| Storage | |
| Target |
Kir6.1, encoded by the KCNJ8 gene, is a member of the inwardly rectifying potassium (Kir) channel family, which plays a critical role in regulating membrane potential and cellular excitability. Unlike voltage-gated potassium channels, Kir channels preferentially allow potassium ions to flow into the cell, stabilizing the resting membrane potential and modulating neuronal responsiveness.
Kir6.1 is a key subunit of ATP-sensitive potassium (K_ATP) channels, which couple cellular metabolic state to electrical activity. While Kir6.1 is predominantly expressed in cardiac and smooth muscle tissues—including fetal and adult hearts—it is also present in the brain, where it contributes to neurovascular coupling and neuronal protection under metabolic stress.
In the nervous system, Kir6.1-containing K_ATP channels are activated during conditions of energy depletion, such as ischemia or oxidative stress, helping to hyperpolarize neurons and reduce excitotoxicity. Dysregulation of Kir6.1 function has been implicated in neurodegenerative diseases, including stroke, Alzheimer’s disease, and Parkinson’s disease, where impaired energy metabolism and ionic imbalance are central pathological features.
Furthermore, mutations in KCNJ8 have been associated with J-wave syndromes and other channelopathies, highlighting the broader physiological importance of Kir6.1 in excitable tissues.
As research into metabolic regulation and ion channel dysfunction in neurodegeneration advances, Kir6.1 is emerging as a promising target for therapeutic intervention aimed at preserving neuronal function and preventing cell death.
A 1:100 dilution of SMC-491 was sufficient for detection of Kir6.1 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-491D — Size: 100 ug: Kir6.1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-491D, RRID: AB_2702549)
- SMC-491D-A390 — Size: 100 ug: Kir6.1 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-491D-A390, RRID: AB_2702550)
- SMC-491D-A488 — Size: 100 ug: Kir6.1 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-491D-A488, RRID: AB_2702551)
- SMC-491D-A594 — Size: 100 ug: Kir6.1 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-491D-A594, RRID: AB_2702553)
- SMC-491D-APC — Size: 100 ug: Kir6.1 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-491D-APC, RRID: AB_2702559)
- SMC-491D-BI — Size: 100 ug: Kir6.1 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-491D-BI, RRID: AB_2702560)
- SMC-491D-FITC — Size: 100 ug: Kir6.1 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-491D-FITC, RRID: AB_2702561)
- SMC-491D-HRP — Size: 100 ug: Kir6.1 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-491D-HRP, RRID: AB_2702562)
- SMC-491D-PCP — Size: 100 ug: Kir6.1 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-491D-PCP, RRID: AB_2702564)
- SMC-491D-RPE — Size: 100 ug: Kir6.1 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-491D-RPE, RRID: AB_2702565)
- SMC-491S — Size: 12 ug: Kir6.1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-491S, RRID: AB_2702549)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Panama B.K., McLerie M., and Lopatin A.N. (2007) Am J Physiol Heart Circ Physiol. 293: H3558-H3567.
3. Munoz V., et al. (2007) Heart Rhythm. 4(4): 487-496.
4. Aguilar-Bryan L., et al. (1998) Physiol Rev. 78(1): 227-245.
