| Field | Specification |
|---|---|
| Alternative names | (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C32H31N3O5 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in methanol: clear colorless solution at 5 mg/ml |
| SMILES | |
| InChIKey | |
| Form | White powder |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
KT5720 is a potent and selective inhibitor of protein kinase A (PKA), acting through competitive inhibition. It does not significantly affect PKC, PKG, or mlCK, making it a valuable tool for studying PKA-specific signaling pathways. In neuroscience, KT5720 is used to investigate the role of PKA in synaptic plasticity, memory formation, and neuronal survival. It is also employed in studies of cell cycle regulation and neuroprotection, particularly in models of neurodegenerative disease.
Classification: Specific target organ toxicity-single exposure (Category 1), H370
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H370 Causes damage to organs.
Precautionary statements:
- P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
- P264 Wash skin thoroughly after handling.
- P270 Do not eat, drink or smoke when using this product.
- P307 + P311 IF exposed: Call a POISON CENTER or doctor/ physician.
- P321 Specific treatment (see supplemental first aid instructions on this label).
- P405 Store locked up.
- P501 Dispose of contents/ container to an approved waste disposal plant
KT5720 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-457)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Gadbois D.M., Crissman H.A., Tobey R.A., & Bradbury E.M. (1992) Pro. Na. Aca. Sci. USA. 89(18): 8626–8630.
