| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 2H-Indol-2-one, 5,6-dichloro-3-(1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene)-1,3-dihydro-Ky19382 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
KY19382 (CAS 2226664-93-1) is a research-grade small molecule supplied by TargetMol.
Alternative names: 2H-Indol-2-one, 5,6-dichloro-3-(1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene)-1,3-dihydro-Ky19382
Physical Properties
| CAS Number | 2226664-93-1 |
|---|---|
| Molecular Formula | C17H11Cl2N3O2 |
| Molecular Weight | 360.19 g/mol |
| SMILES | O=C1C(C=2C(N1)=CC(Cl)=C(Cl)C2)=C3C(=NOC)C=4C(N3)=CC=CC4 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
KY19382 (2H-Indol-2-one, 5,6-dichloro-3-(1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene)-1,3-dihydro-Ky19382) is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3beta( IC50s of 19 and 10 nM, respectively). It activates Wnt/beta-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3beta activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases.
Target(s): Others, Wnt/beta-catenin, GSK-3
Signaling pathway(s): Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Others, Stem Cells
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
When solubility is listed as < 1 mg/mL, the compound dissolves to less than 1 mg per milliliter in water at 25 °C, pH 7.4. Such compounds require an organic co-solvent such as DMSO to prepare a concentrated stock, which is then diluted into aqueous assay buffer. For cell-based assays, keep the final DMSO concentration below 0.1% (v/v) to avoid solvent-induced cytotoxicity.
Use a bath-type ultrasonic cleaner rather than a high-intensity ultrasonic disruptor. Bath sonicators provide gentle, uniform agitation appropriate for dissolving solid compounds without generating cavitation damage or excessive heat. Ensure the solvent tube is fully submerged and use short sonication pulses of 5–10 seconds.
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