| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | NG-Nitroarginine methyl ester hydrochloride |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
L-NAME hydrochloride (CAS 51298-62-5) is a research-grade small molecule supplied by TargetMol.
Alternative names: NG-Nitroarginine methyl ester hydrochloride
Physical Properties
| CAS Number | 51298-62-5 |
|---|---|
| Molecular Formula | C7H15N5O4·HCl |
| Molecular Weight | 269.69 g/mol |
| SMILES | Cl.COC(=O)(CH)(N)CCCNC(=N)N(N+)((O-))=O |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
L-NAME hydrochloride (L-NAME HCl), a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 uM, 15 nM, and 39 nM, for iNOS (mouse) , nNOS (bovine) , and eNOS (human), respectively.
Target(s): NOS, NO Synthase
Signaling pathway(s): Immunology/Inflammation
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Sonication time depends on compound solubility and concentration. In most cases, 1–3 minutes of intermittent bath sonication is sufficient to dissolve small molecule compounds in DMSO. For poorly soluble compounds, warming the solvent to 37–50 °C combined with brief vortexing between sonication pulses can improve dissolution. If the compound remains undissolved, prepare a more dilute stock solution.
Determining the amount based on solution clarity.1. If the prepared solution is clear, it can be prepared in a larger amount for one-time use and stored at 4°C. It is recommended to prepare the solution once a week, as prolonged storage may lead to loss of efficacy. 2. If the prepared solution is a suspension, it is recommended to prepare and use immediately each time.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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