| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | L-NIL HCl |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
L-NIL dihydrochloride (CAS 159190-45-1) is a research-grade small molecule supplied by TargetMol.
Alternative names: L-NIL HCl
Physical Properties
| CAS Number | 159190-45-1 |
|---|---|
| Molecular Formula | C8H19Cl2N3O2 |
| Molecular Weight | 260.16 g/mol |
| SMILES | Cl.Cl.CC(=N)NCCCC(CH)(N)C(O)=O |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
L-NIL HCl is a relatively selective iNOS inhibitor (IC50s: 0.4-3.3, 8-38, and 17-92 uM for iNOS, eNOS, and nNOS). L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
Yes — TargetMol inhibitors can be used in cell-based and in vitro experiments. Prepare a DMSO stock, then dilute into cell culture medium to the desired working concentration, keeping DMSO ≤ 0.1% (v/v) to avoid solvent toxicity. Note that not all compounds have published data for every cell line or assay system; in such cases, perform a dose-response experiment with appropriate positive and vehicle controls to validate efficacy in your specific model.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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