| Field | Specification |
|---|---|
| Target | |
| Alternative names | LAMP2, LAMP-2, Lamp2C, Lysosome-associated membrane glycoprotein 2, Lysosome-associated membrane protein 2, CD107b, CD107 antigen-like family member B, Lysosomal membrane glycoprotein type B, LGP-B, Igp110, Igp2, LampB, MAC3 |
| Accession number | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Purified preparation of mouse liver lysosomal membranes |
| Purification | |
| Cellular localization | |
| Concentration | |
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| Shipping | |
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| Main SKU |
LAMP2 (Lysosome-Associated Membrane Protein 2) is a transmembrane glycoprotein essential for lysosomal function and autophagy. It facilitates the maturation of autophagic vacuoles and the degradation of cellular debris. LAMP2 is expressed in lysosomes, late endosomes, and at the plasma membrane, where it may mediate cell-cell and cell-matrix interactions. In neurodegenerative diseases, LAMP2 deficiency or dysfunction impairs autophagic clearance, leading to the accumulation of toxic proteins and organelles. This contributes to neuronal death in disorders such as Danon disease, Parkinson’s disease, and Alzheimer’s disease. LAMP2 also participates in immune responses, promoting leukocyte adhesion and mast cell activation. Its role in lysosomal trafficking and neuroinflammation underscores its importance as a biomarker and therapeutic target in neurodegeneration.
1 µg/ml of SMC-141 was sufficient for detection of LAMP2 in 20 µg of rat liver microsomes by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-141D — Size: 100 ug: LAMP2 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-141D, RRID: AB_2281134)
- SMC-141D-A390 — Size: 100 ug: LAMP2 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-141D-A390, RRID: AB_2698313)
- SMC-141D-A488 — Size: 100 ug: LAMP2 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-141D-A488, RRID: AB_2698314)
- SMC-141D-A594 — Size: 100 ug: LAMP2 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-141D-A594, RRID: AB_2698316)
- SMC-141D-APC — Size: 100 ug: LAMP2 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-141D-APC, RRID: AB_2698322)
- SMC-141D-BI — Size: 100 ug: LAMP2 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-141D-BI, RRID: AB_2698323)
- SMC-141D-FITC — Size: 100 ug: LAMP2 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-141D-FITC, RRID: AB_2698324)
- SMC-141D-HRP — Size: 100 ug: LAMP2 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-141D-HRP, RRID: AB_2698325)
- SMC-141D-PCP — Size: 100 ug: LAMP2 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-141D-PCP, RRID: AB_2698327)
- SMC-141D-RPE — Size: 100 ug: LAMP2 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-141D-RPE, RRID: AB_2698328)
- SMC-141S — Size: 12 ug: LAMP2 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-141S, RRID: AB_2281134)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
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