| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human LMNTD1 recombinant protein (Position: Y48-E349) was used as the immunogen for the LMNTD1 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
LMNTD1 Antibody / Lamin tail domain-containing protein 1 is a anti-LMNTD1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Rat.
Key elements and design rationale
- Target: LMNTD1
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, FACS, ELISA
Biological background
LMNTD1 is encoded by the LMNTD1 gene located on human chromosome 8p21.3. The protein is approximately 63 kilodaltons and characterized by a conserved lamin tail domain that mediates binding to lamins A/C and chromatin-associated factors. LMNTD1 localizes to the inner nuclear membrane, where it may anchor chromatin regions and participate in gene silencing through lamina-associated domains (LADs).
The LMNTD1 antibody detects a 63 kilodalton band in western blot analysis and shows nuclear rim staining under confocal microscopy. Although its function remains incompletely defined, LMNTD1 is proposed to stabilize nuclear structure during differentiation and respond to mechanical stress transmitted through the cytoskeleton. Expression studies indicate enrichment in testis, brain, and embryonic tissues, suggesting developmental and reproductive roles.
Emerging data suggest LMNTD1 interacts with components of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, potentially influencing nuclear positioning and signal transduction. Altered LMNTD1 expression has been observed in certain cancers and developmental disorders, where disrupted nuclear architecture correlates with genomic instability and transcriptional dysregulation.
By linking nuclear lamina integrity with chromatin organization, LMNTD1 contributes to structural and functional compartmentalization of the nucleus.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
