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Compound Overview
Mergetpa (CAS 77102-28-4) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 77102-28-4 |
|---|---|
| Molecular Formula | C7H15N3O2S2 |
| Molecular Weight | 237.34 g/mol |
| SMILES | O=C(O)C(CS)CSCCNC(=N)N |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Mergetpa, a carboxypeptidase inhibitor, impedes the conversion of kinins and B2 receptor antagonists into metabolites devoid of the C-terminal arginine (1).
Target(s): Carboxypeptidase
Signaling pathway(s): Proteases/Proteasome
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Centrifuge the closed vial at 3000 rpm for 1–2 minutes to consolidate the powder at the bottom. For electrostatically charged powders, briefly warm the vial to room temperature and allow it to equilibrate before opening. Then add the appropriate solvent directly onto the powder and vortex before sonicating. Avoid tapping the vial vigorously, as this can generate fine powder aerosol.
For normal mice, the concentration of DMSO should be kept below 10%. For nude mice, transgenic mice, or mice with weak tolerance, the concentration of DMSO should be kept below 2%. For inhibitors being used for the first time, it is recommended to perform a solvent-negative control experiment to confirm that the solvent has no nonspecific effects on the animals.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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